T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses.

بررسی اثر تماس مستقیم سلولهایT بکر با سلولهای فیبروبلاست تحریک شده با BCG بر القای سلولهایT تنظیمی

Background: Lymph node stromal fibroblasts are interconnected with TCD4+ cells and affect their phenotype and function. Understanding the nature of these interactions under unusual conditions like infections will help to their application in control and regulation of immune responses. Materials and methods: Lymph node fibroblasts were affected in BCG primed immune environment by both in-...

Antiviral immune responses of mice lacking MHC class II or its associated invariant chain.

Induction of T-helper cells and T-B cell interaction have been considered to critically depend upon recognition of major histocompatibility complex (MHC) class II molecules by the T cell receptor. Mice lacking either MHC class II molecules (class II(0/0) mice) or its associated invariant chain (Ii0/0 mice) provide new opportunities to test this premise. Immune responses to some protein antigens...

Section 1: General Aspects of Vaccination How Do Vaccines Mediate Protection?

Disease control or elimination requires the induction of protective immunity in a suffi cient proportion of the population. This is best achieved by immunization programs capable of inducing long-term protection, a hallmark of adaptative immunity that contrasts to the brisk but short-lasting innate immune responses. Long-term immunity is conferred by the maintenance of antigen-specifi c immune ...

Helper Function Requirement for the Induction of NK Cell Th1 and CTL Responses: Two-Signal Dendritic Cells Mediate NK Cell Help for

Functional capacities of T lymphocyte subsets from synovial fluid and blood in rheumatoid arthritis.

A reverse haemolytic plaque forming cell (PFC) assay was employed to analyse the impact of T suppressor/cytotoxic and T helper cells on B cell function in 10 patients with rheumatoid arthritis (RA). In all cases T8-enriched cells from synovial fluid and blood suppressed the pokeweed mitogen (PWM) induced IgM, IgG, and IgA secretion by autologous lymphocytes to the same degree. The suppression w...